Combined Antioxidant Formulation of Ascorbic Acid with Resveratrol Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats

The current investigation was proposed to assess the effectiveness of combination resveratrol and ascorbic acid against Isoproterenol (ISO)-induced myocardial infarction in rats. experimental model divided into six groups (n = 6 each group). Group I: control, 2: isoproterenol (ISO)-100 mg/kg b.wt, 3: ISO+Resveratrol (RES) (20 b.wt) treated, 4: ISO+ Ascorbic (AA) (80 5: ISO+RES b.wt)+AA treated : RES b.wt)+ AA alone treated. study showed an increase lipid peroxides cardiac markers serum samples animals administered with ISO. Treatment individually a combinational formulation brought significant decrease markers. They increased level enzymatic antioxidants non-enzymatic antioxidant levels. Histopathological results distortion heart architecture among ISO recovery when their combination. presents effective combating ISO-induced protection ROS-mediated oxidative stress.